Durham, NC versus St Louis, MO is a real move, not a trivia matchup. This comparison uses the same 2026 neighborhood report data we publish on each city page — typical rent, median household income, crime indexes, school composites, and typical weather — so you can see which city actually fits how you live, work, and spend. Typical rents sit near $1,711 a month in Durham and $1,218 in St Louis, and median household income lands at $74,710 versus $52,941. Open either city's full report when you want the block-level detail behind these headlines.
Durham takes job market and safety, while St Louis takes affordability and weather. The widest gap is median income, where Durham leads by 41% — the kind of spread you feel in a monthly budget or a nightly walk, not just on a chart. Read the category rows as a filter: if cheaper housing would change your life more than a stronger job market, weight rent first. If you are moving with kids, weight schools and crime. If you picked a city after one good weekend, use the weather and income rows to test whether that weekend survives a full year.
Numbers below are citywide, not a guarantee about the street you will actually live on. Two ZIP codes in Durham can feel further apart than Durham and St Louis do on paper. Use this page to pick a city, then use the Durham and St Louis reports to pick a neighborhood — and visit in the season you like least before you sign anything.